Analgesic and Anti-Inflammatory Effect of Ethanol Extract of Tribulus Terrestris L

We evaluate the analgesic and anti-inflammatory potential of ethanol extract of Tribulus terrestris L. (TT) leaves on Wistar rats. Analgesic and anti-inflammatory potential of the ethanol extract of the TT leaves at doses of 50, 100 & 200 mg/kg was evaluated against the standard drug indomethacin at a dose of 20 mg/kg, p.o. Adult Wistar rats of either sex of six numbers in each group was undertaken for study and evaluated by acetic acidinduced writhing, hot plate reaction time, carrageenan-induced hind paw edema and safety test on gastric mucosa method. Ethanol extract of TT showed anti-nociceptive effect in acetic acid-induced writhing characterized by a significant decrease in the number of writhings in rats (p < 0.01). In hot plate test, TT showed nociceptive reaction towards thermal stimuli in rats and a significant increase in the reaction time was observed (p < 0.01). The test drug significantly inhibited the carrageenan-induced hind paw edema in rats that is indicative of the antiinflammatory effect of TT (p < 0.01). However, no gastric lesions were observed in TT treated rats indicating the safety of test drug. The ethanol extract of TT showed significant analgesic and anti-inflammatory potential in different animal models.